Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 330-332.doi: 10.4103/1673-5374.317976

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Stem cell-based 3D brain organoids for mimicking, investigating, and challenging Alzheimer’s diseases

Federica Cordella, Carlo Brighi, Alessandro Soloperto*, Silvia Di Angelantonio*   

  1. Center for Life Nanoscience, Istituto Italiano di Tecnologia, Rome, Italy (Cordella F, Brighi C, Soloperto A, Di Angelantonio S)
    Department of Physiology and Pharmacology, Sapienza University, Rome, Italy (Cordella F, Brighi C, Di Angelantonio S)
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Alessandro Soloperto, PhD, alessandro.soloperto@iit.it; Silvia Di Angelantonio, PhD, silvia.diangelantonio@uniroma1.it.

Abstract: Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder that causes a decline of cognitive functions and a deterioration of behavioral and social performances. According to current estimations, AD is considered the prevalent cause of dementia, accounting for 60% and 80% of cases every year. The etiology of the disease is related to both genetic and environmental factors, making AD a cultifactorial disorder, with a major classification as late-onset AD and early-onset AD.