Abstract: Exploring the Alzheimer’s disease neuroepigenome: recent advances and future trends: Alzheimer’s disease (AD) is a chronic neurodegenerative disease and the most common cause of dementia. After decades of ongoing efforts by scientists, many hallmarks of AD, such as amyloid-β (Aβ) and tau pathologies, have finally been understood. But these milestone discoveries still failed to help us find a cure. In recent years, based on advances in genomics, researchers have discovered more than 20 AD-associated alleles. Three of these alleles can cause autosomal dominant AD: amyloid precursor protein and presenilin 1/2 genes. The rest of these alleles can increase the risk to AD, such as the apolipoprotein E gene. These risk loci implicate Aβ, tau, immunity, and lipid processing, which have helped us accurately understand the complex changes in AD patients’ molecular networks.