Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (2): 409-417.doi: 10.4103/1673-5374.317992

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Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota

Yi-Tong Lin1, #, Qing-Qing Shi1, #, Lei Zhang1, #, Cai-Ping Yue1, Zhi-Jun He1, Xue-Xia Li1, Qian-Jun He2, Qiong Liu1, Xiu-Bo Du1, 3, *   

  1. 1College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen, Guangdong Province, China; 2Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong Province, China; 3Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, China
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Xiu-Bo Du, PhD, duxiubo@szu.edu.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, No. 21771126 (to XBD); and the Shenzhen Bureau of Science, Technology and Information of China, No. JCYJ20180305124000597 (to XBD).

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Abstract: Hydrogen exhibits the potential to treat Alzheimer’s disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer’s disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer’s disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer’s disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.

Key words: Alzheimer’s disease, amyloid-β, anti-inflammation, bioenergetics, gut microbiota, hydrogen therapy, neurodegenerative disease, neurofibrillary tangles

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