Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (8): 1711-1716.doi: 10.4103/1673-5374.332130

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Myeloperoxidase: a new target for the treatment of stroke?

Yun-Chang Wang1, 2, 3, #, Yu-Bao Lu1, 2, 4, #, Xiao-Lan Huang5, Yong-Feng Lao1, Lu Zhang1, Jun Yang1, Mei Shi1, Hai-Long Ma1, Ya-Wen Pan1, 2, *, Yi-Nian Zhang1, 2, *   

  1. 1The Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China; 2Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China; 3Xiangya Hospital, Central South University, Changsha, Hunan Province, China; 4Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China; 5University of Chinese Academy of Sciences, Beijing, China
  • Online:2022-08-15 Published:2022-01-21
  • Contact: Yi-Nian Zhang, MD, PhD, ery_zhangyinian@lzu.edu.cn; Ya-Wen Pan, MD, PhD, panyawen666@sohu.com.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81771297 (to YNZ); CuiYing Scientific and Technological Innovation Program of Lanzhou University Second Hospital of China, No. CY2017-MS04 (to YNZ); Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment of China, No. LZU-JZH2224 (to YCW); National Innovation and Entrepreneurship Training Program for Undergraduate of China, No. 201910730212 (to YCW); and CuiYing Scientific Training Program for Undergraduates of Lanzhou University Second Hospital of China, No. CYXZ2019-06 (to YCW).

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Abstract: Myeloperoxidase is an important inflammatory factor in the myeloid system, primarily expressed in neutrophils and microglia. Myeloperoxidase and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke, including damage to the blood-brain barrier and brain. As a specific inflammatory marker, myeloperoxidase can be used in the evaluation of vascular disease occurrence and development in stroke, and a large amount of experimental and clinical data has indicated that the inhibition or lack of myeloperoxidase has positive impacts on stroke prognosis. Many studies have also shown that there is a correlation between the overexpression of myeloperoxidase and the risk of stroke. The occurrence of stroke not only refers to the first occurrence but also includes recurrence. Therefore, myeloperoxidase is significant for the clinical evaluation and prognosis of stroke. This paper reviews the potential role played by myeloperoxidase in the development of vascular injury and secondary brain injury after stroke and explores the effects of inhibiting myeloperoxidase on stroke prognosis. This paper also analyzes the significance of myeloperoxidase etiology in the occurrence and development of stroke and discusses whether myeloperoxidase can be used as a target for the treatment and prediction of stroke.

Key words: blood-brain barrier, hemorrhagic stroke, inflammation, ischemic stroke, microglia, myeloperoxidase, neutrophils, secondary brain injury, stroke