Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (9): 1961-1962.doi: 10.4103/1673-5374.335148

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Heme as an inducer of cerebral damage in hemorrhagic stroke: potential therapeutic implications

Luiz Ricardo da Costa Vasconcellos*, Pedro Moreno Pimentel-Coelho   

  1. Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, London, UK (Vasconcellos LRC) 
    Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa, Rio de Janeiro, RJ, Brazil (Pimentel-Coelho PM)
  • Online:2022-09-15 Published:2022-03-05
  • Contact: Luiz Ricardo da Costa Vasconcellos, PhD,luiz.vasconcellos@crick.ac.uk.
  • Supported by:
    LRCV received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (No. 845908).

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Abstract: Intracerebral hemorrhage (ICH) consists of the rupture of a cerebral artery leading to bleeding into the surrounding parenchyma. This event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect, followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding (Bulters et al., 2018). Despite the high rates of mortality and morbidity from ICH, no effective treatment is available so far.