Abstract: Alzheimer’s disease (AD) mouse models have proven to be an invaluable tool for deepening our understanding of disease mechanisms and for developing therapeutics. However, one common frustration is the lack of replicability in behavioral findings. As we have discussed in our recent publication (Cho et al., 2021), in the htau mouse model, the cognitive impairment reported in the original study has not been consistently replicated by different labs over the past decade. This variability in behavioral findings seems to exist in many, if not all, AD mouse models that have been behaviorally evaluated.