Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (10): 2211-2212.doi: 10.4103/1673-5374.335792

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The integrative role of G protein-coupled receptor heterocomplexes in Parkinson’s disease

Dasiel O. Borroto-Escuela, Kjell Fuxe   

  1. Department of Neuroscience, Karolinska Institutet, Biomedicum, Stockholm, Sweden
  • Online:2022-10-15 Published:2022-03-16
  • Contact: Dasiel O. Borroto-Escuela, PhD, dasiel.borroto.escuela@ki.se; Kjell Fuxe, PhD, kjell.fuxe@ki.se.
  • Supported by:
    This work was supported by grants from the Swedish Medical Research Council (04X-715) to KF, by Olle Engkvists Stiftelse to KF and DOBE, and from Hjärnfonden (F02019-0296), Karolinska Institutet Forskningsstiftelser and EMERGIA 2020-39318 (Plan Andaluz de Investigación, Desarrollo e Innovación 2020) to DOBE. DOBE belongs to Academia de Biólogos Cubanos.

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Abstract: In the 1950s to 1970s, the research on Parkinson’s disease (PD) and its treatment had mainly been focused on the Nigro-striatal dopamine (DA) neurons as the major site of degeneration in this disease. It contributed to the search for drugs that restored DA transmission in this pathway and contributed to the introduction of L-DOPA and DA receptor agonists in its treatment (Borroto-Escuela and Fuxe, 2019).