Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (10): 2102-2107.doi: 10.4103/1673-5374.335825

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Role of platelet-derived extracellular vesicles in traumatic brain injury-induced coagulopathy and inflammation

Liang Liu, Quan-Jun Deng   

  1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China
  • Online:2022-10-15 Published:2022-03-15
  • Contact: Quan-Jun Deng, MD, dqj2177@163.com.
  • Supported by:
    This work is supported by Scientific Research Program of Tianjin Education Commission (Natural Science) of China, No. 2019ZD034 (to QJD).

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Abstract: Extracellular vesicles are composed of fragments of exfoliated plasma membrane, organelles or nuclei and are released after cell activation, apoptosis or destruction. Platelet-derived extracellular vesicles are the most abundant type of extracellular vesicle in the blood of patients with traumatic brain injury. Accumulated laboratory and clinical evidence shows that platelet-derived extracellular vesicles play an important role in coagulopathy and inflammation after traumatic brain injury. This review discusses the recent progress of research on platelet-derived extracellular vesicles in coagulopathy and inflammation and the potential of platelet-derived extracellular vesicles as therapeutic targets for traumatic brain injury.

Key words: angiogenesis, clotting factors, coagulopathy, delivery, inflammation, platelet-derived extracellular vesicles, review, target, traumatic brain injury