Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (11): 2399-2403.doi: 10.4103/1673-5374.335835

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Advancements in our understanding of circular and long non-coding RNAs in spinal cord injury

Yan Zhang1, Ho Jun Yun2, Yu Ji1, 3, Eric Cosky2, Wen-Xiu Zhang1, Wei Han1, 3, *, Yu-Chuan Ding2, *   

  1. 1Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, China; 2Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA; 3Department of General Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China
  • Online:2022-11-15 Published:2022-04-21
  • Contact: Wei Han, MD, PhD, dr-han1972@mail.ccmu.edu.cn; Yu-Chuan Ding, MD, PhD, yding@med.wayne.edu.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, No. 81901241 (to YZ).

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Abstract: Spinal cord injury (SCI), either from trauma or degenerative changes, can result in severe disability and impaired quality of life. Understanding the cellular processes and molecular mechanisms that underlie SCI is imperative to identifying molecular targets for potential therapy. Recent studies have shown that non-coding RNAs, including both long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), regulate various cellular processes in SCI. In this review, we will describe the changes in lncRNA and circRNA expression that occur after SCI and how these changes may be related to SCI progression. Current evidence for the roles of lncRNAs and circRNAs in neuronal cell death and glial cell activation will also be reviewed. Finally, the possibility that lncRNAs and circRNAs are novel modulators of SCI pathogenesis will be discussed.

Key words: circular RNAs, function, long non-coding RNAs, neuronal cells, neuronal glia, pathogenesis, regulation, spinal cord injury