Neural Regeneration Research ›› 2022, Vol. 17 ›› Issue (11): 2407-2412.doi: 10.4103/1673-5374.335837

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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

Amsha S. Alsegiani, Zahoor A. Shah*   

  1. Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH, USA
  • Online:2022-11-15 Published:2022-04-21
  • Contact: Zahoor A. Shah, Ph.D, zahoor.shah@utoledo.edu.
  • Supported by:
    ASA was supported by the College of Pharmacy, Department of Pharmaceutical Chemistry, King Saud University, Riyadh, Saudi Arabia. The study was partly supported by the grants from The American Heart Association, No. 17AIREA33700076/ZAS/2017 and the National Institute of Neurological Disorders and Stroke of the National Institutes of Health, No. R01NS112642 (to ZAS).

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Abstract: Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attracted significant attention. Age-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative disorders. Aging is one of the critical predisposing risk factors for the development of neurodegenerative diseases. Maintaining a healthy gut microbiota is essential for a healthy body and aging, but dysbiosis could initiate many chronic diseases. Understanding the underlying mechanisms of gut microbiota alterations/dysbiosis will help identify biomarkers for aging-related chronic conditions. This review summarizes recent advances in microbiota-neurodegenerative disease research and will enhance our understanding of gut microbiota dysbiosis and its effects on brain aging.

Key words: brain aging, cognitive decline, dysbiosis, fecal microbiota transplantation, gut-microbiota, neuroinflammation, prebiotics, probiotics