Abstract: Towards implanted deep brain stimulation (DBS): The human brain is a complex network of 86 billion neurons and 85 billion nonneuronal cells and they are coordinated in a well-defined ratio (1:1) which is required for desired body functions. The connectivity among neuronal cells secretes neurotransmitters (e.g., dopamine) to establish a perfect connection between the brain and a peripheral system i.e., motor coordination. The secretion of neurotransmitters was found to be affected by aspects of lifestyle, age, and deteriorated health can damage the neurons’ connectivity, which can cause neurodegeneration leading to neurological disorders (Wang and Guo, 2016; Kumar et al., 2021). Circuit disturbances resulting from changes within the synapses, cells’ intrinsic excitability, and impaired connectivity within local networks and between projection areas mediate neurodegenerative disease and are associated symptomatic features (Werner et al., 2019; McTeague et al., 2020; Vissani et al., 2020). Disruptions in neural circuitry have also been demonstrated to underly emotional processing across various psychiatric conditions (Werner et al., 2019). In this context, techniques for adequate circuit reconstruction offer therapeutic potential. The lack of effective treatment made this situation very complicated to manage and in need of alternative treatment strategies, which are always in high demand. As a result of this, introducing external stimulation to modulate electrical communication among neurons’ circuitry is getting attention for understanding the neurobiology needed for diagnostics and treatment (Kozielski et al., 2021).