Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 521-522.doi: 10.4103/1673-5374.346471

Previous Articles     Next Articles

Choroid plexus imaging to track neuroinflammation – a translational model for mouse and human studies

Muthuraman Muthuraman*, #, Mohammadsaleh Oshaghi#, Vinzenz Fleischer, Dumitru Ciolac, Ahmed Othman, Sven G. Meuth, Gabriel Gonzalez-Escamilla, Sergiu Groppa   

  1. Department of Neurology, Focus Program Translational Neuroscience, Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (Muthuraman M, Oshaghi M, Fleischer V, Ciolac D, Gonzalez-Escamilla G, Groppa S)
    Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany (Othman A)
    Department of Neurology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany (Meuth SG)
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Muthuraman Muthuraman, PhD, mmuthura@uni-mainz.de.
  • Supported by:
    This work was supported by the German Research Foundation (DFG): SFB-TR-128 (to SG and MM), MU 4354/1-1(to MM) and the Boehringer Ingelheim Fonds BIF-03 (to SG and MM).

PDF

64

Abstract: The choroid plexus (ChP) is a highly vascularized and secretory tissue in each of the brain ventricles that represents the key structure between the blood and the cerebrospinal fluid (CSF). Besides its essential role in CSF production and brain waste clearance pathways, the ChP also contributes to the regulation of central nervous system (CNS) immunosurveillance (Ghersi-Egea et al., 2018). Indeed, the ChP forming the blood-CSF barrier (BCSFB) regulates the entry of immune cells and solute molecules into the brain and vice versa. When antigen-specific, autoreactive immune activation occurs in the periphery, inflammatory cells migrate through the brain barriers towards the CNS (Strominger et al., 2018), initiating neuroinflammatory diseases such as multiple sclerosis (MS).