Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 506-512.doi: 10.4103/1673-5374.350187

Previous Articles     Next Articles

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury

Qing-Sheng Li1, 2, Yan-Jie Jia1, *    

  1. 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China; 2Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China
  • Online:2023-03-15 Published:2022-08-25
  • Contact: Yan-Jie Jia, MD, PhD, jiayanjie1971@zzu.edu.cn.
  • Supported by:
    The work was supported by the National Natural Science Foundation of China, No. U1604170 (to YJJ).

PDF

59

Abstract: Ferroptosis, a new non-necrotizing programmed cell death (PCD), is driven by iron-dependent phospholipid peroxidation. Ferroptosis plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries. The inhibitors against ferroptosis effectively improve iron homeostasis, lipid metabolism, redox stabilization, neuronal remodeling, and functional recovery after trauma. In this review, we elaborate on the latest molecular mechanisms of ferroptosis, emphasize its role in secondary central nervous trauma, and update the medicines used to suppress ferroptosis following injuries. 

Key words: ferroptosis, immune response, inflammation, iron homeostasis, lipid metabolism, medicine, programmed cell death, spinal cord injury, traumatic brain injury