Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 554-555.doi: 10.4103/1673-5374.350199

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Brain-derived neurotrophic factor in main neurodegenerative diseases

Serena Camuso, Sonia Canterini*   

  1. Division of Neuroscience, Department of Psychology, University La Sapienza, Rome, Italy (Camuso S, Canterini S)
    PhD Program in Behavioral Neuroscience, Sapienza University of Rome, Rome, Italy (Camuso S)
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Sonia Canterini, PhD, sonia.canterini@uniroma1.it.
  • Supported by:
    This work was supported by “Sapienza” University (Ateneo2021_ RP12117A8857C5F8 to SC).

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Abstract: Discovered in pig brains in 1982, the brain-derived neurotrophic factor (BDNF) is one of the most studied and characterized neurotrophins in the central nervous system. In recent years, BDNF has received considerable attention for its importance in the development and maintenance of normal brain function. This is because BDNF plays an important role in crucial functions of the nervous system, such as the survival, differentiation, and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions, such as glutamatergic overstimulation, cerebral ischemia, hypoglycemia, and neurotoxicity (Kowiański et al., 2018).