Abstract: Ischemic retinopathy is a retinal disease caused by ischemic attacks. Ischemia is a common pathologic mechanism in various retinal disorders and diseases such as age-related macular degeneration, diabetic retinopathy, glaucoma, or vascular occlusion (Osborne et al., 2004). Although various murine models have been developed to understand a series of metabolic mechanisms induced by retinal ischemia and further used to test promising therapeutics, effective treatment in ischemic retinopathy has not been clearly suggested. This is associated with the notion that the contributing pathologic metabolic pathways might be enormously complex.