Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (8): 1730-1731.doi: 10.4103/1673-5374.363191

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Data and subject heterogeneity and data sharing: keys to translational success in spinal cord injury research?

Karim Fouad, Olivia H. Wireman, John C. Gensel*#br#   

  1. Faculty of Rehabilitation Medicine, Department of Physical Therapy, Neuroscience and Mental Health Institute, University of Alberta, Alberta, Canada (Fouad K)
    Spinal Cord and Brain Injury Research Center (SCoBIRC), Department of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA (Wireman OH, Gensel JC)
  • Online:2023-08-15 Published:2023-02-23
  • Contact: John C. Gensel, PhD, gensel.1@uky.edu.
  • Supported by:
    This work was supported by NIH, Nos. NIH R01 NS116068 (to JCG) and NIH T32 NS077889 (to OHW). 

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Abstract: Spinal cord injury (SCI) is a highly devastating and complex injury with many secondary consequences. Finding a treatment for SCI has been a rollercoaster ride through exciting peaks and sobering valleys. As a matter of fact, there are still no robust and reliable clinical treatments to minimize or repair spinal cord damage. The reasons are manifold and in this opinion piece, we will argue that subject heterogeneity and a lack of transparency in reporting findings are potential contributors to the challenge of finding and translating treatments from the bench to the bedside.