Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (9): 1940-1941.doi: 10.4103/1673-5374.363827

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Tissue optical clearing for neural regeneration research

Tingting Yu#, Jianyi Xu#, Dan Zhu*   

  1. Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility, Huazhong University of Science and Technology, Wuhan, Hubei Province, China (Yu T, Xu J, Zhu D)
    Optics Valley Laboratory, Wuhan, Hubei Province, China (Yu T, Xu J, Zhu D) 
  • Online:2023-09-15 Published:2023-03-06
  • Contact: Dan Zhu, PhD, dawnzh@mail.hust.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China (Grant Nos. 61860206009 (to DZ), 81870934 (to DZ), and 81961138015 (to TY)), Innovation Project of Optics Valley Laboratory (Grant No. OVL2021BG011) (to DZ), and the Innovation Fund of WNLO (to DZ).

Abstract: Nerve injury, whether traumatic or degenerative, disrupts the transmission of information in the nervous system, leading to dysfunction. It is widely known that neural regeneration is vital to the restoration of function after nerve injury. Still, outcomes are often limited by the misguidance of axonal regeneration and complex pathological changes in neurons and glia, as well as the long-term denervation of target organs. Morphological analyses of neural tissues and target organs are vital for outcome assessments in neural regeneration research.