Abstract: Ischemic stroke: Stroke is the second and third cause of death and disability, respectively, with an annual rate of 24.9 million cases worldwide (Chidambaram et al., 2022). Stroke is defined as the lack of blood supply to a specific area of the brain, accounting for 85% of all cases (Chidambaram et al., 2022). Changes in the gut microbiota have also been reported as risk factor for stroke (Pluta et al., 2021; Tan et al., 2021; Chidambaram et al., 2022). Post-stroke neurodegeneration is multifactorial characterized by neuronal death, amyloid plaques, neurofibrillary tangles, a neuroinflammatory response, a lack of acetylcholine, and a cognitive deficit with full-blown dementia (approximately 50% survivors) (Yuan et al., 2020; Pluta 2022).