Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (11): 2381-2382.doi: 10.4103/1673-5374.371353

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Gut-brain axis: does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development? 

Arianna Casciati, Mariateresa Mancuso, Roberta Vitali*, Simonetta Pazzaglia*   

  1. Biomedical Technologies Laboratory, Agenzia Nazionale per le Nuove Tecnologie, l’Energia e lo Sviluppo Economico Sostenibile (ENEA), Rome, Italy
  • Online:2023-11-15 Published:2023-05-04
  • Contact: Simonetta Pazzaglia, PhD, simonetta.pazzaglia@enea.it; Roberta Vitali, PhD, roberta.vitali@enea.it.
  • Supported by:
    This work was supported by the NANOCROSS project “Plant virus nanoparticles for blood-brain barrier crossing and medulloblastoma targeting” granted by the Italian Association for Cancer Research: IG 20314 to MM.

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Abstract: Gut-brain axis: does intestinal inflammation affect hippocampal neurogenesis and medulloblastoma development? Inflammatory bowel diseases (IBD) are a group of disorders that cause chronic inflammation in the intestines, associated with altered intestinal permeability, which in turn causes an immune response to enteric antigens in a genetically susceptible host. IBD incidence is high in industrialized countries and continuously rises in emerging economies.