Abstract: The cerebral cortex is composed of billions of neurons and glia that are generated sequentially during corticogenesis. These cells are generated in an organized fashion during development. At early stages of brain development, neural stem cells (NSCs) undergo symmetric divisions to expand their pool. Subsequently, most NSCs begin to undergo asymmetric cell divisions to maintain the NSC pool and generate basal progenitors (BPs) that are committed to neuronal differentiation (Mukhtar and Taylor, 2018). BPs divide once or twice and subsequently differentiate into immature newborn neurons (NBNs), which migrate along radial glial fibers to the pial surface of the developing brain. Upon reaching the brain surface, they begin to differentiate to give rise to the respective cortical layers (Figure 1A). Finally, NSCs switch their fate to generate glial cells. Thus, the three phases of corticogenesis can be defined as NSC expansion, neurogenesis, and gliogenesis, which correspond to the main mode of NSC division and the differentiation fate of their progeny into neurons and glia, respectively (Mukhtar and Taylor, 2018).