Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (2): 316-323.doi: 10.4103/1673-5374.379019

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Mitophagy in intracerebral hemorrhage: a new target for therapeutic intervention

Yiyang Chen1, 2, Wenxuan Tang1, Xinqi Huang1, Yumei An1, Jiawen Li1, Shengye Yuan1, Haiyan Shan3, *, Mingyang Zhang1, 2, *   

  1. 1Institute of Forensic Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu Province, China; 2Shanghai Key Lab of Forensic Medicine, Key Lab of Forensic Science, Ministry of Justice (Academy of Forensic Science), Shanghai, China; 3Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China
  • Online:2024-02-15 Published:2023-08-30
  • Contact: Haiyan Shan, MD, PhD, ghostqth@163.com; Mingyang Zhang, MD, PhD, mingyangzhang@suda.edu.cn.
  • Supported by:
    This work was supported by the National Natural Science Foundation of China, Nos. 82071382 (to MZ), 81601306 (to HS); The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) (to MZ); Jiangsu 333 High-Level Talent Training Project (2022) (to HS); The Jiangsu Maternal and Child Health Research Key Project, No. F202013 (to HS); Jiangsu Talent Youth Medical Program, No. QNRC2016245 (to HS); Shanghai Key Lab of Forensic Medicine, No. KF2102 (to MZ); Suzhou Science and Technology Development Project, No. SYS2020089 (to MZ); The Fifth Batch of Gusu District Health Talent Training Project, No. GSWS2019060 (to HS).

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Abstract: Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae. However, there is currently no treatment available for intracerebral hemorrhage, unlike for other stroke subtypes. Recent studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral hemorrhage. Mitophagy, or selective autophagy of mitochondria, is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged mitochondria. Mitophagy markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral hemorrhage. This review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it, and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage, aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral hemorrhage. In conclusion, although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far, most of which are in the preclinical stage and require further investigation, mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

Key words: intracerebral hemorrhage, mitochondrial dysfunction, mitophagy, neuroinflammation, neuroprotection, reactive oxygen species, secondary brain injury, therapeutic target