Abstract: Damage to the spinal cord disrupts the electrically active nerve cells which normally transmit afferent and efferent signals, resulting in loss of motor, sensory, and autonomic functions. Potential treatments for spinal cord injury utilizing implanted spinal electrodes can be broadly classified into three different categories. The first of these approaches is “spinal stimulation” where electrodes, usually positioned above the level of injury, provide electrical stimulation to target and disrupt pain signals before they reach the brain. The second approach uses “activity-dependent neuro-technologies”, in which electrodes positioned below the level of injury initiate a complex spatiotemporal pattern of stimulation at the lumbar spinal cord to generate a walking gait in the limbs (Minev et al., 2015; Wagner et al., 2018). The third treatment approach has been coined “electroceuticals”, in which a pair of electrodes positioned close to and either side of a spinal cord injury site generate a low-frequency electric field to promote regrowth and direct axons to reconnect across the damaged region (Shapiro, 2014). Most research studies or clinical applications utilizing these approaches use the epidural placement of the electrodes, in which the electrodes are placed in the epidural space (Figure 1). In contrast, our research group is developing an implant to deliver electroceutical treatments designed to be inserted underneath the dura mater, which is referred to as intradural or subdural positioning (Harland et al., 2022; Figure 1). We are currently using this implant to test different electrical field treatments in a preclinical model while looking ahead to how such a device may be translated to a clinical setting. Therefore, in this perspective, we will explore the advantages and challenges associated with intradural placement of electrodes in the spinal cord and discuss the current and future feasibility of clinical implantation of intradural electrodes and devices.