Abstract: In patients, as well as in animal models, hypersensitivity to external stimuli (hyperalgesia and allodynia) or spontaneous pain is often the first, and the most disabling, symptom of neuropathy (Davis et al., 2020). The increased activity of sensitive neurons drives pain development, making ion channel modulation a fundamental target for current pharmacotherapy as well as one of the most investigated by the R&D departments of pharmaceutical companies (Bennett et al., 2019).