Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (6): 1291-1298.doi: 10.4103/1673-5374.385848

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Neuroprotective effects of chaperone-mediated autophagy in neurodegenerative diseases

Qi Jia1, #, Jin Li1, 2, #, Xiaofeng Guo1, #, Yi Li1, You Wu1, Yuliang Peng1, Zongping Fang1, 3, *, Xijing Zhang1, *   

  1. 1Department of Anesthesiology and Perioperative Medicine and Department of Intensive Care Unit, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi Province, China; 2Department of Critical Care Medicine, Air Force Medical Center, Beijing, China; 3Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
  • Online:2024-06-15 Published:2023-11-17
  • Contact: Xijing Zhang, PhD, xjzhang0806@163.com; Zongping Fang, PhD, zongping03@163.com.
  • Supported by:
    This work was supported by the National Nature Science Foundation of China, Nos. 81871603 (to XZ) and 82171322 (to ZF); Discipline Boost Program of the First Affiliated Hospital of Air Force Military Medical University, No. XJZT21J08 (to XZ); and the Natural Science Foundation of Shaanxi Province of China, No. 2022KJXX-102 (to ZF).

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Abstract: Chaperone-mediated autophagy is one of three types of autophagy and is characterized by the selective degradation of proteins. Chaperone-mediated autophagy contributes to energy balance and helps maintain cellular homeostasis, while providing nutrients and support for cell survival. Chaperone-mediated autophagy activity can be detected in almost all cells, including neurons. Owing to the extreme sensitivity of neurons to their environmental changes, maintaining neuronal homeostasis is critical for neuronal growth and survival. Chaperone-mediated autophagy dysfunction is closely related to central nervous system diseases. It has been shown that neuronal damage and cell death are accompanied by chaperone-mediated autophagy dysfunction. Under certain conditions, regulation of chaperone-mediated autophagy activity attenuates neurotoxicity. In this paper, we review the changes in chaperone-mediated autophagy in neurodegenerative diseases, brain injury, glioma, and autoimmune diseases. We also summarize the most recent research progress on chaperone-mediated autophagy regulation and discuss the potential of chaperone-mediated autophagy as a therapeutic target for central nervous system diseases.

Key words: chaperone-mediated autophagy, neurodegenerative disease, neuronal homeostasis,  , neuroprotection