Abstract: Implications for lncRNAs in the central nervous system: Transcriptional dysregulation is a key contributor to the pathogenesis of a wide range of diseases and long non-coding RNAs (lncRNAs) are highly expressed in the nervous system. Indeed, amongst the over 50,000 lncRNAs expressed in the human genome, more than 40% are specifically expressed in the brain where their roles in brain development, neuron functions, maintenance, and differentiation, are becoming increasingly evident (Zhou et al., 2021). In addition, some lncRNAs were found to have a role in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and Alzheimer’s disease, along with an interesting link to the physiological aging process (Rey et al., 2021; Zhou et al., 2021). Interestingly, RNA-sequencing analysis conducted in peripheral blood mononuclear cells of sporadic ALS patients and matched controls highlighted 293 differentially expressed lncRNAs contributing to corroborate the importance of lncRNAs in ALS (Gagliardi et al., 2018). Amongst the top ten deregulated lncRNAs identified the most dysregulated antisense of transcription-related genes was Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1), antisense to the ZEB1 gene (Gagliardi et al., 2018, Garofalo et al., 2020).