Abstract: Aging is associated with chronic form of inflammation called inflammaging, which results from immune system changes. Inflammaging plays a crucial role in the pathogenesis of various neurodegenerative diseases (Dabravolski et al., 2022). Moreover, aging-related inflammation can be triggered by disrupted mitophagy, where the accumulation of molecular patterns associated with mitochondrial damage in the cytosol leads to the production of inflammatory cytokines and activation of the immune response. In our recent research, we investigated the impact of aging and mitochondrial dysfunction on neuroinflammation using a model of central nervous system (CNS) neuroinflammation in mice that lack genes associated with familial Parkinson’s disease (PD; Figure 1).