Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (6): 1173-1174.doi: 10.4103/1673-5374.385874

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The immune system: uncharted pathways between senses and the brain

Noelia Casares, Mar Cuadrado-Tejedor, Ana García-Osta, Juan José Lasarte*   

  1. Immunology and Immunotherapy Program, Centre for Applied Medical Research (CIMA), University of Navarra, IDISNA, Pamplona, Spain (Casares N, Lasarte JJ)
    Division of Gene Therapy for Neurological Disorders, Centre for Applied Medical Research (CIMA), University of Navarra, IDISNA, Pamplona, Spain (Cuadrado-Tejedor M, García-Osta A) 
    Pathology, Anatomy and Physiology Department, School of Medicine, University of Navarra, IDISNA, Pamplona, Spain (Cuadrado-Tejedor M)
  • Online:2024-06-15 Published:2023-11-17
  • Contact: Juan José Lasarte, PhD, jjlasarte@unav.es.
  • Supported by:
    This work was supported by a grant from the Department of Economic and Business Development from the Government of Navarra (INNOLFACT project; Ref. 0011-1411-2023-000094). 

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Abstract: Humans and animals use the classic five senses -sight, hearing, touch, smell, and taste- to detect and monitor their environment, with the sense of position and movement often referred to as the sixth sense. The perception of external signals through the senses is essential to an organism’s survival, transmitting signals to the central nervous system (CNS) and prompting physiological changes in other biological systems. In addition to the direct effects of sense-induced mediators in the brain, the perception of external signals can significantly affect the immune system that in turn can also affect the CNS and cognition.