Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (8): 1651-1652.doi: 10.4103/1673-5374.389633

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Modifying the progression of Parkinson’s disease through movement interventions: multimodal quantification of underlying mechanisms

Manuel Bange, Damian Marc Herz, Dumitru Ciolac, Gabriel Gonzalez-Escamilla, Sergiu Groppa*#br#   

  1. Section of Movement Disorders and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany
  • Online:2024-08-15 Published:2024-01-03
  • Contact: Sergiu Groppa, MBA, segroppa@uni-mainz.de.

Abstract: Introduction: Parkinson’s disease (PD) is the most common neurodegenerative movement disorder. The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta, which is accompanied by widespread alterations in the structure and function of distributed brain networks. Together, these processes cause a variety of motor symptoms such as bradykinesia, rigidity, tremor, gait disorders, or difficulties in fine motor control (Bange et al., 2022).