Abstract: Introduction: Traumatic brain injury (TBI) is a common diagnosis among veterans secondary to combat experiences. TBI is also rampant among those experiencing homelessness, possibly due to veterans making up 12.3% of the homeless population (Tsai and Rosenheck, 2015), or due to the high risk of violence or trauma among those experiencing homelessness. TBI is up to 10× more prevalent among those experiencing homelessness (Stubbs et al., 2020; Dell et al., 2021). In a study involving 1215 patients, 58% of patients discharged from trauma centers without stable housing were diagnosed with TBI compared to 48% of those discharged to a home (Dell et al., 2021). In a meta-analysis of 9702 homeless or unstably housed individuals, the lifetime prevalence of TBI was 53.1% (Stubbs et al., 2020). TBI has known underlying neuroinflammatory changes, and the chronic stressors of homelessness may further contribute to systemic inflammation (Brisson et al., 2020). Our research team questioned whether the additional stress associated with homelessness may exacerbate the functional deficits and pathophysiological changes in TBI.