Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (11): 2513-2521.doi: 10.4103/1673-5374.391309

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OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

  

  1. Department of Neurology, Jiangxi Provincial People’s Hospital, Xiangya Hospital Jiangxi Hospital of Central South University, The Clinical College of Nanchang Medical College, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China
  • Online:2024-11-15 Published:2024-03-29
  • Contact: Renshi Xu, MD, PhD, xurenshi@ncu.edu.cn or 13767015770@163.com.
  • Supported by:
    The study was supported by the National Natural Science Foundation of China, Nos. 30560042, 81160161, 81360198, 82160255; a grant from Department of Education of Jiangxi Province, Nos. GJJ13198, GJJ170021; Jiangxi Provincial Department of Science and Technology, Nos. [2014]-47, 20142BBG70062, 20171BAB215022, 20192BAB205043; and Science and Technology Plan of Jiangxi Commission of Health, Nos. 202210002, 202310119 (all to RX).

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Abstract: Amyotrophic lateral sclerosis is a neurodegenerative disease, and the molecular mechanism underlying its pathology remains poorly understood. However, inflammation is known to play an important role in the development of this condition. To identify driver genes that affect the inflammatory response in amyotrophic lateral sclerosis, as well as potential treatment targets, it is crucial to analyze brain tissue samples from patients with both sporadic amyotrophic lateral sclerosis and C9orf72-related amyotrophic lateral sclerosis. Therefore, in this study we used a network-driven gene analysis tool, NetBID2.0, which is based on SJARACNe, a scalable algorithm for the reconstruction of accurate cellular networks, to experimentally analyze sequencing data from patients with sporadic amyotrophic lateral sclerosis. The results showed that the OSMR gene is pathogenic in amyotrophic lateral sclerosis and participates in the progression of amyotrophic lateral sclerosis by mediating the neuroinflammatory response. Furthermore, there were differences in OSMR activity and expression between patients with sporadic amyotrophic lateral sclerosis and those with C9orf72-related amyotrophic lateral sclerosis. These findings suggest that OSMR may be a diagnostic and prognostic marker for amyotrophic lateral sclerosis.

Key words: amyotrophic lateral sclerosis, driver, neuroinflammation, OSMR, C9ORF72, neurodegenerative disease, pathogenesis, oxidative stress, protein misfolding, mitochondrial dysfunction