Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (11): 2351-2353.doi: 10.4103/1673-5374.392876

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Fish-on-Chips: unveiling neural processing of chemicals in small animals through precise fluidic control

Samuel K. H. Sy*, Ho Ko   

  1. Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China (Sy SKH, Ko H)
    Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China (Sy SKH, Ko H)
    Department of Electrical and Electronic Engineering, Faculty of Engineering, The University of Hong Kong, Pok Fu Lam, Hong Kong Island, Hong Kong Special Administrative Region, China (Sy SKH)
    Advanced Biomedical Instrumentation Center, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China (Sy SKH)
    Margaret K. L. Cheung Research Center for Management of Parkinsonism, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China (Ko H) 
    Lau Tat-chuen Research Center of Brain Degenerative Diseases in Chinese, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China (Ko H) 
    Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China (Ko H)
  • Online:2024-11-15 Published:2024-03-28
  • Contact: Samuel K. H. Sy, PhD, khsamuelsy@gmail.com.
  • Supported by:
    This work was funded by a Croucher Innovation Award (CIA20CU01) from the Croucher Foundation; the General Research Fund (14100122), the Collaborative Research Fund (C6027-19GF & C7074-21GF), and the Area of Excellence Scheme (AoE/M-604/16) of the Research Grants Council, the University Grants Committee of Hong Kong, China; the Excellent Young Scientists Fund (Hong Kong and Macao, China) (82122001) from the National Natural Science Foundation of China; the Lo’s Family Charity Fund Limited (all to HK).

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Abstract: Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals. Nevertheless, the dynamic nature of chemical-carrying media, such as water or air, poses a significant challenge for delivering highly-controlled chemical flow to an animal subject. Moreover, contact-based cue manipulation and delivery easily shift the position of the animal subject, which is often undesirable for high-quality brain imaging. Additionally, more advanced interfacing tools that align with the diverse range of body part sizes of an animal, ranging from micrometer-scale neurons to meter-long limbs, are much needed. This is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.