Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (12): 2569-2570.doi: 10.4103/NRR.NRR-D-23-01971

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Sex differences in Alzheimer’s disease: an urgent research venue to follow

Raquel Jiménez-Herrera#, Ana Contreras#, Juan D. Navarro-López*, Lydia Jiménez-Díaz*   

  1. Neurophysiology & Behavior Lab, University of Castilla-La Mancha, School of Medicine of Ciudad Real, Ciudad Real, Spain
  • Online:2024-12-15 Published:2024-03-30
  • Contact: Lydia Jiménez-Díaz, PhD, Lydia.Jimenez@uclm.es; Juan D. Navarro-López, PhD, Juan.Navarro@uclm.es.
  • Supported by:
    This work was supported by grants PID2020–115823-GB100 funded by MCIN/AEI/10.13039/501100011033, and SBPLY/21/180501/000150 funded by JCCM/ERDF - A way of making Europe, and 2022-GRIN-34354 grant by UCLM/ERDF intramural funding to LJD and JDNL. AC held a Margarita Salas Postdoctoral Research Fellow (2021-MS-20549) funded by European Union NextGenerationEU/PRTR.

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Abstract: Due to increasing life expectancy, the amount of people with dementia worldwide is expected to experience a substantial rise, with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the year 2050. Among the various forms of dementia, Alzheimer’s disease (AD) stands out as the predominant and most prevalent. According to the Alzheimer’s Association (No authors listed, 2023), nearly two thirds of AD patients in the US are women and similar numbers are found in Europe. Both the “pandemic” incidence and demographic disparity emphasize the importance of studying AD with a sex-inclusive approach.