Abstract: Glial progenitor cells were reported to have the capacity to generate various types of cells in both the central nervous system (CNS) and peripheral nervous system. Glial progenitor cells can respond to diverse environmental signals and transform into distinct populations, each serving specific functions. Notably, the adult spinal cord hosts various populations of glial progenitors, a region integral to the central nervous system. During development, glial progenitors express glial fibrillary acidic protein (GFAP; Dimou and Gotz, 2014). However, the specific identities of GFAP-expressing progenitors in the adult spinal cord were not thoroughly investigated. Glial progenitors in the adult spinal cord may hold more heterogeneity and plasticity than previously thought.