Abstract: The neuromuscular junction (NMJ) is an essential synaptic structure composed of motor neurons, skeletal muscles, and glial cells that orchestrate the critical process of muscle contraction (Li et al., 2018). The typical NMJ structure is classically described as having a “pretzel-like” shape in mice (Figure 1), whereas human NMJs have a smaller, fragmented structure throughout adulthood. Degenerated NMJs exhibit smaller or fragmented endplates, partial denervation, reduced numbers of synaptic vesicles, abnormal presynaptic mitochondria, and dysfunctional perisynaptic Schwann cells (Alhindi et al., 2022).