Abstract: The brain, with its trillions of neural connections, d i ffe re n t c e l l u l a r t y p e s , a n d m o l e c u l a r complexities, presents a formidable challenge for researchers aiming to comprehend the multifaceted nature of neural health. As traditional methods have provided valuable insights, emerging technologies offer unprecedented o p p o r t u n i t i e s to d e l v e d e e p e r i nt o t h e underpinnings of brain function. In the everevolving landscape of neuroscience, the quest to unravel the mysteries of the human brain is bound to take a leap forward thanks to new technological improvements and bold interpretative frameworks. Indeed, as our understanding of the intricacies of the human brain advances, so does the need for comprehensive and integrative approaches to studying brain health in a synergistic manner, bridging the gap between biology (e.g., molecular pathways), interactions (e.g., environmental influences), and advanced computational analyses (e.g., explainable artificial intelligence). Brain health, therefore, is not just about understanding brain function in and of itself; it is about comprehending its complex relational networks with the surrounding environment (represented by physiological, psychological, or external stimuli) and putting this information at the service of personalized well-being through precision medicine.