Abstract: The brain’s extracellular matrix (ECM), which is comprised of protein and glycosaminoglycan (GAG) scaffolds, constitutes 20%–40% of the human brain and is considered one of the largest influencers on brain cell functioning (Soles et al., 2023). Synthesized by neural and glial cells, the brain’s ECM regulates a myriad of homeostatic cellular processes, including neuronal plasticity and firing (Miyata et al., 2012), cation buffering (Morawski et al., 2015), and glia–neuron interactions (Anderson et al., 2016). Considering the diversity of functions, dynamic remodeling of the brain’s ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.