Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory functions. In only approximately 5% of the cases, AD is familial, as often predisposed by genetic mutations (Hoogmartens et al., 2021), while sporadic AD accounts for approximately 95% of the cases. The amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β (Aβ) peptides that leads to the accumulation of Aβ plaques in the parenchyma, an anatomical hallmark of AD.