Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (9): 2591-2593.doi: 10.4103/NRR.NRR-D-24-00734

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Emerging potential of progranulindependent SorCS2 signaling in healthy and diseased nervous systems

Alena Salasova* , Anders Nykjær   

  1. Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine, and Centre of Excellence PROMEMO, Department of Biomedicine, Aarhus University, Aarhus, Denmark
  • Online:2025-09-15 Published:2024-12-28
  • Contact: Alena Salasova, PhD, alena.salasova@biomed.au.dk.
  • Supported by:
    We thank Lucie Kuncova and Sierra Lyn Wittrup Olsen for critically reading the manuscript draft. This work was supported by Danish National Research Foundation (#DNRF133) (to AN).

Abstract: The formation of the mammalian nervous system and its maturation into sensory, motor, cognitive, and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood. Impaired neurodevelopment can result in various neurological and psychiatric conditions, jointly named neurodevelopmental disorders (NDDs). Today ’s stringent NDD classification includes intellectual disabilities, communication disorders, autism spectrum disorder, attention-deficit hyperactivity disorder, movement disorders, and specific learning disorders. While the NDD incidence is on the rise, the available therapies are limited and provide only symptomatic relief (Cainelli and Bisiacchi, 2022).