Abstract: Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets, resulting in the loss of motor and sensory functions. Despite the peripheral nervous system’s capacity for axonal regrowth, this may lead to permanent impairements resulting in a loss of quality of life and a high socioeconomic burden. For example, peripheral nerve injuries in the upper extremities are relatively common, especially due to work-related accidents, and can lead to significant morbidity and long-term costs. A study found that 30% of patients with work-related nerve injuries experienced permanent disabilities, requiring financial compensation and impacting their quality of life. The estimated lifetime cost per patient with severe injury, including treatment, rehabilitation, and compensation, is approximately €102,167, highlighting the substantial economic impact of these injuries (Bergmeister et al., 2020).