Abstract: Alzheimer’s disease (AD) is the most common form of dementia, affecting millions worldwide. It is characterized by progressive cognitive decline and changes in behavior and personality, attributed to neuropathological changes, such as amyloid-beta (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. While microglia, the resident immune cells in the brain, are well established as contributors in AD disease progression, recently, T cells in the periphery and the brain have also been highlighted as being important in the progression of AD, with CD8+ T cells reducing amyloid-β pathology and neurodegeneration by interacting with microglia (Su et al., 2023), while increasing tau-mediated neurodegeneration (Chen et al., 2023), showing the possibility of T cells to effect AD neuropathological changes, at least in animal models with specific and isolated AD-related pathologies.