Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (1): 300-301.doi: 10.4103/NRR.NRR-D-24-01136

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Extra-pineal melatonin in perisynaptic Schwann cell–muscle fiber cross talk at the regenerating neuromuscular junction

Samuele Negro* , Cesare Montecucco* , Michela Rigoni*   

  1. Department of Biomedical Sciences, University of Padua, Padua, Italy (Negro S, Montecucco C, Rigoni M) CNR Institute of Neuroscience, Padua, Italy (Montecucco C)
  • Online:2026-01-15 Published:2025-04-23
  • Contact: Samuele Negro, PhD, samuele.negro1987@gmail.com; Cesare Montecucco, cesare.montecucco@gmail.com;
  • Supported by:
    This work was supported by the University of Padua (to MR), by the project “RIPANE” of the Italian Ministry of Defense (to CM) , and by Cariparo Foundation (to CM).

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Abstract: The neuromuscular junction and its proregenerative niche: The mammalian peripheral nervous system, unlike the central nervous system, has preserved throughout evolution the ability to regenerate and fully restore function. Key factors for effective nerve regeneration include a supportive neuronal environment and a coordinated tissue response (Brosius Lutz and Barres, 2014)