Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (4): 1560-1561.doi: 10.4103/NRR.NRR-D-24-01310

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Peripheral nervous system and gut microbiota: Emerging evidence on increased mechanistic understanding to reveal innovative strategies for peripheral nerve regeneration

Giulia Ronchi* , Matilde Cescon, Giovanna Gambarotta, Kirsten Haastert-Talini   

  1. Department of Clinical and Biological Sciences & Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Torino, Orbassano, Italy (Ronchi G, Gambarotta G) Department of Molecular Medicine, University of Padova, Padova, Italy (Cescon M) Institute of Neuroanatomy and Cell Biology, Hannover Medical School; Centre for Systems Neuroscience (ZSN), Hannover, Germany (Haastert-Talini K)
  • Online:2026-04-15 Published:2025-07-27
  • Contact: Giulia Ronchi, PhD, giulia.ronchi@unito.it.
  • Supported by:
    This work was supported by the European UnionNext Generation EU, Mission 4 Component 1, Project Title: “Gut and NeuroMuscular system: investigating the impact of microbiota on nerve regeneration and muscle reinnervation after peripheral nerve injury”, CUP D53D23007770006, MUR: 20227YB93W, to GR.

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Abstract: The gut microbiota: The human body is colonized by a diverse and complex microbial community – including bacteria, viruses, archaea, and unicellular eukaryotes – that plays a central role in human wellbeing. Indeed, microbiota is crucial for several functions, including host metabolism, physiology, maintenance of the intestinal epithelial integrity, nutrition, and immune function, earning it the designation of a “vital organ” (Guinane and Cotter, 2013).