Abstract: Aging is a universal biological process characterized by the progressive decline in cellular and tissue function, representing the main risk factor for the development of most chronic human diseases. At the cellular level, one hallmark of aging is the accumulation of senescent cells—non-dividing yet metabolically active cells that adopt a unique phenotype, including the senescence-associated secretory phenotype (SASP) (Wang et al., 2024). The SASP encompasses a complex secretory program of bioactive molecules, including proinflammatory cytokines such as interleukin-6, interleukin-1 beta, and tumor necrosis factoralpha; chemokines such as CXC motif chemokine ligand 8/interleukin-8 and C-C motif chemokine ligand 2; growth factors such as vascular endothelial growth factor and hepatocyte growth factor; and matrix-remodeling enzymes such as matrix metalloproteinases. These factors influence the surrounding microenvironment by promoting inflammation, tissue remodeling, and paracrineinduced senescence. While the SASP may play a beneficial role in acute stress responses such as wound healing and tumor suppression, its chronic persistence contributes to systemic inflammation, stem cell exhaustion, and age-associated pathologies (Wang et al., 2024).