Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (7): 2944-2945.doi: 10.4103/NRR.NRR-D-25-00567

Previous Articles     Next Articles

Reevaluating the role of skeletal muscle in amyotrophic lateral sclerosis pathogenesis: Insights from muscle-derived factors

Pablo Martinez, Brigitte van Zundert, Fernando J. Bustos*   

  1. Department of Neurology, Baylor College of Medicine, Houston, TX, USA
    Institute of Biomedical Sciences (ICB), Faculty of Medicine & Faculty of Life Sciences, Universidad Andres Bello, Santiago, Chile 
    Millennium Nucleus of Neuroepigenetics and Plasticity (EpiNeuro), Santiago, Chile
  • Online:2026-07-15 Published:2026-03-27
  • Contact: Fernando J. Bustos, PhD, Fernando.bustos@unab.cl.
  • Supported by:
    This work was supported by ANID Fondecyt Regular 1250955 (to FJB), ANID Fondecyt Regular 1221745 (to BvZ), UNAB DI-06-24/REG (to FJB), and ANID MILENIO (NCN2023_32, to BvZ and FJB).

PDF

14

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease marked by motor neuron (MN) degeneration, neuromuscular junction disruption, and muscle atrophy, ultimately leading to paralysis and death. Despite extensive research, no effective treatment exists, highlighting the need to elucidate mechanisms driving ALS pathogenesis.