Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (9): 4223-4224.doi: 10.4103/NRR.NRR-D-25-01197

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Role of the subthalamic nucleus in motor control

Gabriel González-Escamilla*, Nils Schöter, Sergiu Groppa   

  1. Department of Neurology, Saarland University, Homburg, Germany (González-Escamilla G, Schöter N, Groppa S)
    Department of Neurology, Saarland University Medical Center, Homburg, Germany (González-Escamilla G, Schöter N, Groppa S)
  • Online:2026-09-15 Published:2026-05-11
  • Contact: Gabriel González-Escamilla, PhD, Gabriel.Gonzalez@uks.eu.

Abstract: Situated below the thalamus, the subthalamic nucleus (STN) functions as an excitatory relay within the indirect pathway, influencing both the suppression of involuntary movements and fine motor execution. While the STN has traditionally been associated with motor inhibition, emerging evidence highlights its complex connectivity with cortical, striatal, pallidal, and brainstem structures, enabling precise modulation of movement intensity, timing, and coordination.