Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (9): 4267-4268.doi: 10.4103/NRR.NRR-D-25-01793

Previous Articles     Next Articles

Gene delivery to the mouse brain: Facilitating disease modeling and gene therapy

Osama Ahmed, Aliaa Elshamy, Abraam Yakoub*   

  1. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA (Ahmed O, Yakoub A)
    Department of Biomedical Engineering, University of North Dakota, Grand Forks, ND, USA (Ahmed O)
    Department of Microbiology and Immunology, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt (Elshamy A)
  • Online:2026-09-15 Published:2026-05-14

PDF

6

Abstract: Gene delivery to the mouse brain is essential for neural circuit probing or therapeutic testing. We describe viral approaches for gene delivery to the mouse brain, and outline the applications and limitations of each approach, and strategies to mitigate the limitations. We provide a decisionoriented guide to the optimal vector and route combinations for the mouse brain, to facilitate studying brain functions or testing gene therapies in vivo.