Alzheimer’s disease, a progressive neurodegenerative illness, is the most common form of dementia. So far, there is neither an effective prevention nor a cure for Alzheimer’s disease. In recent decades, stem cell therapy has been one of the most promising treatments for Alzheimer’s disease patients. This article aims to summarize the current progress in the stem cell treatments for Alzheimer’s disease from an experiment to a clinical research.

Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (1): 66-71.

Alzheimer’s disease, a progressive neurodegenerative illness, is the most common form of dementia. So far, there is neither an effective prevention nor a cure for Alzheimer’s disease. In recent decades, stem cell therapy has been one of the most promising treatments for Alzheimer’s disease patients. This article aims to summarize the current progress in the stem cell treatments for Alzheimer’s disease from an experiment to a clinical research.

Received:2011-10-08 Revised:2011-12-02 Online:2012-01-05 Published:2012-01-05
Contact: Jun Tang, Department of Laboratory Medicine and Pathology,Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW Rochester, MN 55905, USA Tang.Jun@mayo.edu
About author:Jun Tang☆, Ph.D., M.D., Department of Laboratory Medicine and Pathology,Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW Rochester, MN 55905, USA

Abstract

Jun Tang. Alzheimer’s disease, a progressive neurodegenerative illness, is the most common form of dementia. So far, there is neither an effective prevention nor a cure for Alzheimer’s disease. In recent decades, stem cell therapy has been one of the most promising treatments for Alzheimer’s disease patients. This article aims to summarize the current progress in the stem cell treatments for Alzheimer’s disease from an experiment to a clinical research.[J]. Neural Regeneration Research, 2012, 7(1): 66-71.

[1]	Yu Li, Ping-Ping Shen, Bin Wang. Induced pluripotent stem cell technology for spinal cord injury: a promising alternative therapy [J]. Neural Regeneration Research, 2021, 16(8): 1500-1509.
[2]	Sara Saffari, Tiam M. Saffari, Dietmar J. O. Ulrich, Steven E. R. Hovius, Alexander Y. Shin. The interaction of stem cells and vascularity in peripheral nerve regeneration [J]. Neural Regeneration Research, 2021, 16(8): 1510-1517.
[3]	Xue-Mei Zhang, Yang Sun, Ying-Lian Zhou, Zhuo-Min Jiao, Dan Yang, Yuan-Jiao Ouyang, Mei-Yu Yu, Jin-Yue Li, Wei Li, Duo Wang, Hui Yue, Jin Fu. Therapeutic effects of dental pulp stem cells on vascular dementia in rat models [J]. Neural Regeneration Research, 2021, 16(8): 1645-1651.
[4]	Yong-Bin Gao, Zhi-Gang Liu, Guo-Dong Lin, Yang Guo, Lei Chen, Bo-Tao Huang, Yao-Bin Yin, Chen Yang, Li-Ying Sun, Yan-Bo Rong, Shanlin Chen. Safety and efficacy of a nerve matrix membrane as a collagen nerve wrapping: a randomized, single-blind, multicenter clinical trial [J]. Neural Regeneration Research, 2021, 16(8): 1652-1659.
[5]	Qiang Gao, Aaron Leung, Yong-Hong Yang, Benson Wui-Man Lau, Qian Wang, Ling-Yi Liao, Yun-Juan Xie, Cheng-Qi He. Extremely low frequency electromagnetic fields promote cognitive function and hippocampal neurogenesis of rats with cerebral ischemia [J]. Neural Regeneration Research, 2021, 16(7): 1252-1257.
[6]	Min Wang, Juan-Juan Tang, Lin-Xiao Wang, Jun Yu, Li Zhang, Chen Qiao. Hydrogen sulfide enhances adult neurogenesis in a mouse model of Parkinson’s disease [J]. Neural Regeneration Research, 2021, 16(7): 1353-1358.
[7]	Shinichi Kinoshita, Ryuta Koyama. Pro- and anti-epileptic roles of microglia [J]. Neural Regeneration Research, 2021, 16(7): 1369-1371.
[8]	Dae Young Yoo, Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Hyun Jung Kwon, Sung Min Nam, Jin Young Chung, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang. Entacapone promotes hippocampal neurogenesis in mice [J]. Neural Regeneration Research, 2021, 16(6): 1005-1010.
[9]	Jian Zhang, Ren-Jie Wang, Miao Chen, Xiao-Yin Liu, Ke Ma, Hui-You Xu, Wu-Sheng Deng, Yi-Chao Ye, Wei-Xin Li, Xu-Yi Chen, Hong-Tao Sun. Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury [J]. Neural Regeneration Research, 2021, 16(6): 1068-1077.
[10]	Yuan Liu, Richard K. Lee. Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma [J]. Neural Regeneration Research, 2021, 16(6): 1138-1141.
[11]	Natalia E. Krzesniak, Anna Sarnowska, Anna Figiel-Dabrowska, Katarzyna Osiak, Krystyna Domanska-Janik, Bartłomiej H. Noszczyk. Secondary release of the peripheral nerve with autologous fat derivates benefits for functional and sensory recovery [J]. Neural Regeneration Research, 2021, 16(5): 856-864.
[12]	Xue-Mei Zhang, Yuan-Jiao Ouyang, Bing-Qian Yu, Wei Li, Mei-Yu Yu, Jin-Yue Li, Zhuo-Min Jiao, Dan Yang, Na Li, Ying Shi, Yun-Yun Xu, Zhi-Jun He, Duo Wang, Hui Yue, Jin Fu. Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease [J]. Neural Regeneration Research, 2021, 16(5): 893-898.
[13]	Mariam Rizk, Justin Vu, Zhi Zhang. Impact of pediatric traumatic brain injury on hippocampal neurogenesis [J]. Neural Regeneration Research, 2021, 16(5): 926-933.
[14]	Lindsey H. Forbes, Melissa R. Andrews. Advances in human stem cell therapies: pre-clinical studies and the outlook for central nervous system regeneration [J]. Neural Regeneration Research, 2021, 16(4): 614-617.
[15]	Zhi-Hai Ju, Xuan Liang, Yao-Yao Ren, Luo-Wa Shu, Yan-Hong Yan, Xu Cui. Neurons derived from human-induced pluripotent stem cells express mu and kappa opioid receptors [J]. Neural Regeneration Research, 2021, 16(4): 653-658.

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments