Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (11): 842-848.

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The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system*

Maoguang Yang, Minfei Wu, Peng Xia, Chunxin Wang, Peng Yan, Qi Gao, Jian Liu, Haitao Wang, Xingwei Duan, Xiaoyu Yang   

  1. Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China
  • Received:2012-02-07 Revised:2012-03-08 Online:2012-04-15 Published:2012-04-15
  • Contact: Xiaoyu Yang, Professor, Doctoral supervisor, Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China; Xingwei Duan, M.D., Working in People’s Hospital of Shenzhen Baoan District yangxiaoyu88@sina.com
  • About author:Maoguang Yang☆, Studying for doctorate, Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China

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Abstract:

In this review, we discuss the role of microtubule-associated protein 1B (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components, and regulate the stability and interaction of microtubules and actin to promote axonal growth, neural connectivity and regeneration in the central nervous system.

Key words: microtubule-associated protein 1B, central nervous system, axonal regeneration, axonal development, axon guidance, neuronal migration