Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (35): 2801-2810.

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Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration

Jiasharete Jielile1, Minawa Aibai2, Gulnur Sabirhazi3, Nuerai Shawutali1, Wulanbai Tangkejie1,Aynaz Badelhan1, Yeermike Nuerduola1, Turde Satewalede1,Darehan Buranbai1, Beicen Hunapia1, Ayidaer Jialihasi1, Jingping Bai4, Murat Kizaibek5   

  1. 1 Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China
    2 Urumqi Center for Disease Control and Prevention, Urumqi 830026, Xinjiang Uyghur Autonomous Region, China
    3 Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
    4 Department of Orthopedics, Third Teaching Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
    5 The Research Institute of Kazakh Traditional Medicine of Ili Kazakh Autonomous Prefecture of Xinjiang, Yining 835000, Ili Kazakh Autonomous Prefecture of Xinjiang, China
  • Received:2012-08-18 Revised:2012-11-04 Online:2012-12-15 Published:2012-12-15
  • Contact: Jingping Bai, M.D., Ph.D.,Professor, Department of Orthopedics, Third Teaching Hospital of Xinjiang Medical University, No.30, Beijing South Road, Urumqi 830011,Xinjiang Uyghur Autonomous Region, China jingping_bai@163.com
  • About author:Jiasharete Jielile☆, M.D.,Ph.D., Associate professor,Department of Microsurgical Repair and Reconstruction,First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region,China

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Abstract:

Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon.However,protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achilles tendon rupture. The tendon was then immobilized or subjected to postoperative early motion treatment (kinesitherapy). Mass spectrography results showed that after 14 days of motion treatment, 18 protein spots were differentially expressed, among which, 12 were up-regulated, consisting of gelsolin isoform b and neurite growth-related protein collapsing response mediator protein 2. Western blot analysis showed that gelsolin isoform b was up-regulated at days 7–21 of motion treatment. These findings suggest that active Achilles tendon kinesitherapy promotes the neurite regeneration of a ruptured Achilles tendon and gelsolin isoform b can be used as a biomarker for Achilles tendon healing after kinesitherapy.

Key words: achilles tendon rupture, early, motion, functional exercise, exercise, Achilles tendon, healing;proteomics, marker, tissue repair