Neural Regeneration Research ›› 2013, Vol. 8 ›› Issue (35): 3306-3315.doi: 10.3969/j.issn.1673-5374.2013.35.005

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Bushen Yisui Capsule ameliorates axonal injury in experimental autoimmune encephalomyelitis

Ling Fang1, Qi Zheng1, Tao Yang2, Hui Zhao1, Qiuxia Zhang1, Kangning Li2, Li Zhou2, Haiyang Gong2, Yongping Fan2, Lei Wang1   

  1. 1 School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
    2 Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
  • Received:2013-08-04 Revised:2013-11-15 Online:2013-12-15 Published:2013-12-15
  • Contact: Lei Wang, Ph.D., Professor, Doctoral supervisor, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China, tmwangl@ccmu. edu.cn. Yongping Fan, Ph.D., Professor, Chief physician, Doctoral supervisor, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China, yongpingf@hotmail.com.
  • About author:Ling Fang, Studying for master’s degree.
  • Supported by:

    This study was supported by the National Natural Science Foundation of China, No. 81072765, 81173237, 81273742; Scientific Research Key Project of Beijing Municipal Commission of Education, No. KZ201310025023; and Special Fund for Capital Traditional Chinese Medicine and Nursing Research, No. 12ZYH01.

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Abstract:

A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early multiple sclerosis remains unclear. In this study, a MOG35–55-immunized C57BL/6 mouse model of experimental au-toimmune encephalomyelitis was intragastrically administered Bushen Yisui Capsule. The results showed that Bushen Yisui Capsule effectively improved clinical symptoms and neurological function of experimental autoimmune encephalomyelitis. In addition, amyloid precursor protein expression was down-regulated and microtubule-associated protein 2 was up-regulated. Experimental findings indicate that the disease-preventive mechanism of Bushen Yisui Capsule in experimental autoim-mune encephalomyelitis was mediated by amelioration of axonal damage and promotion of regen-eration. But the effects of the high-dose Bushen Yisui Capsule group was not better than that of the medium-dose and low-dose Bushen Yisui Capsule group in preventing neurological dysfunction.